Fig. 4
From: Integrative cross-species analysis reveals conserved and unique signatures in fatty skeletal muscles
Clustering and transcriptional dynamics of myofibers nuclei in different species. (a) UMAP plot showing six subclusters of the isolated single nuclei from aged human and high IMF content pig muscles. (b) UMAP and violin plot displaying the expression of selected marker genes for each subcluster of myofibers nuclei. (c) Nuclei proportion in each subcluster in different species. Each cluster is color-coded. (d) Volcano plot representing the top 10 most DEGs by bimod difference analysis algorithm (P-Value < 0.01, Log2FC ≥ 0.26) between cell subclusters identified and KEGG enrichment for marker genes of each cell type in different species. I, type I myonuclei; IIA, type IIa myonuclei; IIX, type IIx myonuclei; Type IIB, type IIb myonuclei; MTJ, myotendinous junction nuclei; NMJ, neuromuscular junction nuclei.
