Table 3 PKT Human Disease Knowledge Graph Primary Edge Types by Relation.

participates in (RO_0000056)

has participant (RO_0000057)

chemical-pathway; gene-pathway; protein-biological process; protein-pathway

has function (RO_0000085)

function of (RO_0000079)

pathway-molecular function; protein-molecular function

located in (RO_0001025)

location of (RO_0001015)

protein-anatomy; protein-cell^a; protein-cellular component; transcript-anatomy; transcript-cell^a

has component (RO_0002180)^b

pathway-cellular component

has phenotype (RO_0002200)

phenotype of (RO_0002201)

disease-phenotype

has gene product (RO_0002205)

gene product of (RO_0002204)

gene-protein

interacts with (RO_0002434)^c

chemical-gene; chemical-protein

genetically interacts with (RO_0002435)^c

gene-gene

molecularly interacts with (RO_0002436)^c

chemical-biological process; chemical-cellular component; chemical-molecular function; protein-catalyst; protein-cofactor; protein-protein

transcribed to (RO_0002511)

transcribed from (RO_0002510)

gene-transcript

ribosomally translates to (RO_0002513)

ribosomal Translation of (RO_0002512)

transcript-protein

causally influences (RO_0002566)

causally influenced by (RO_0002559)

variant-gene

is substance that treats (RO_0002606)

is treated by substance (RO_0002302)

chemical-disease; chemical-phenotype

causes or contributes to condition (RO_0003302)^b

gene-disease; gene-phenotype; variant-disease; variant-phenotype

realized in response to (RO_0009501)^b

biological process-pathway