Fig. 1

Landscape of senescence signature and the prediction of prognosis in TCGA pan-cancer. (A) Senescence signature across 33 TCGA tumor types, ordered by median. (B) The senescence signature increased among CS clusters 1–3 in pan-cancer (Wilcoxon test, all P < 0.0001). (C) Comparison of ages between CS groups defined by senescence signature score percentile in pan-cancer (Wilcoxon test, all P < 0.0001). (D,E) Kaplan-Meier curves of overall survival among 3 CS clusters (log-rank test, P = 1.13e-66) and 5 CS groups (log-rank test, P = 7.21e-26) in pan-cancer. (F) We developed a new CS prediction model and established a portal website to apply this prediction model to predict the prognosis of patients with pan-cancer (https://bio-pub.shinyapps.io/cs_nomo/).