Fig. 1

Lesions associated to hypoxic ischemic encephalopathy (HIE) are typically diffuse (i.e., multi-focal) and small. Here we show two representative images for 3 HIE patients. For each patient, in the left panel: apparent diffusion coefficient (ADC) maps that are clinically used to identify HIE lesions; in the right panel: manually-annotated lesions (shown in pink) overlaid on the ADC map. We listed the percentage of the whole brain volume (including ventricles) being injured at the bottom (i.e., lesion volume divided by the whole brain volume).