Fig. 3
The generation and concept of ZADC maps. (a) Examples of ADC maps from normative subjects, which were warped into the same space using unbiased group-wise DRAMMS registration to generate (b) the mean and standard deviation ADC atlases. (c) One (yellow dashed box) or two (green solid box) standard deviations above and below the mean ADC atlas define the normal ranges of voxel-wise ADC variations. (d) Our novel ZADC map quantifies voxel-wise deviations from the mean ADC map in (b). The cool/warm colors in (d) represent voxels with ADC values lower/higher than the mean ADC at the same anatomic location, according to the scale bar on the right.
