Table 1 Clinical characteristics of the enrolled PMP patients.

From: Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing

 

Discovery cohort

TMA cohort

P value*

1st cohort (n = 5)

2nd cohort (n = 12)

3rd cohort (n = 25)

4th cohort (n = 45)

Age at operation, year

61 ± 6

62 ± 13

56.88 ± 12

58.81 ± 12

0.67

Sex

    

0.84

 Male

2 (40)

3 (25)

10 (40)

16 (36)

 

 Female

3 (60)

9 (75)

15 (60)

29 (64)

 

Operation time, min

459 ± 267

453 ± 199

302 ± 215

300 ± 191

0.06

Hospital stay, day

15 ± 6

14 ± 7

13 ± 6

13 ± 8

0.96

BMI

20.76 ± 2.82

24.75 ± 1.99

24.07 ± 2.94

24.15 ± 2.77

0.05

Follow-up period, month

21 ± 7

45 ± 33

60 ± 45

51 ± 41

0.24

PreCEA

    

0.35

 <5

2 (40)

4 (33)

4 (16)

6 (13)

 

 >5

3 (60)

8 (67)

12 (48)

26 (58)

 

 unknown

0 (0)

0 (0)

9 (36)

13 (29)

 

PCI, 0-39

30 ± 8

23 ± 7

22 ± 10

21 ± 10

0.33

LVI

    

0.70

 Yes

0 (0)

0 (0)

2 (8)

4 (9)

 

 No

4 (80)

8 (67)

15 (60)

33 (73)

 

 unknown

1 (20)

4 (33)

8 (32)

8 (18)

 

PNI

    

0.12

 Yes

0 (0)

0 (0)

1 (4)

1 (2)

 

 No

4 (80)

4 (33)

14 (56)

34 (76)

 

 unknown

1 (20)

8 (67)

10 (40)

10 (22)

 

Histological grading

    

0.71

 Low

4 (80)

12 (100)

19 (76)

35 (78)

 

 High or SRC

1 (20)

0 (0)

6 (24)

10 (22)

 

Recurrence

    

0.06

 Yes

1 (20)

9 (75)

19 (76)

34 (76)

 

 No

4 (80)

3 (25)

6 (24)

11 (24)

 

Postoperative complication

    

0.81

 Yes

4 (80)

9 (75)

16 (64)

29 (64)

 

 No

1 (20)

3 (25)

9 (36)

16 (36)

 

Comorbidity

    

0.80

 Yes

3 (60)

7 (58)

11 (44)

21 (47)

 

 No

2 (40)

5 (42)

14 (56)

24 (53)

 

IP chemo. or HIPEC

    

0.06

 Yes

4 (80)

9 (75)

10 (40)

18 (40)

 

 No

1 (20)

3 (25)

15 (60)

27 (60)

 

CCR

    

0.23

 0 or 1

4 (80)

8 (67)

10 (40)

21 (47)

 

 2 or 3

1 (20)

4 (33)

15 (60)

24 (53)

 
  1. Values are presented as mean ± SD or case number (%).
  2. *Comparison by ANOVA or χ2 tests.
  3. Abbreviations: PMP, psuedomyxoma peritonei; BMI, body mass index; LVI, lymphovascular invasion; PNI, perineural invasion; SRC, signer-ring cell; CEA, carcinoembryonic antigen; PreCEA, preoperation CEA; IP chemo., intraperitoneal chemotherapy; HIPEC, hyperthermic intraperitoneal chemotherapy; CCR, completeness of cytoreduction (0: no macroscopic, 1: < 2.5 mm, 2: 2.5mm–2.5 cm, 3: > 2.5 cm); PCI, peritoneal carcinoma index.