Table 2 Comparison between training and test populations of the retrospective ALS task-specific datasets. Continuous variables are presented as medians (interquartile range); categorical variables as count (percentage on available data), for each level.

Male

733 (51.19%)

185 (53.47%)

901 (53.66%)

236 (55.92%)

908 (52.91%)

268 (55.14%)

Female

699 (48.81%)

161 (46.53%)

778 (46.34%)

186 (44.08%)

808 (47.09%)

218 (44.86%)

Age at onset

64.87 [56.60-71.64]

64.70 [55.46-70.76]

65.04 [56.76-71.82]

64.76 [55.66-70.42]

65.35 [57.20-72.10]

65.01 [56.95–70.86]

Onset Axial

3 (0.21%)

3 (0.87%)

29 (1.73%)

11 (2.60%)

30 (1.75%)

12 (2.57%)

Onset Bulbar

442 (30.86%)

105 (30.35%)

489 (29.12%)

123 (29.15%)

543 (31.64%)

147 (30.25%)

Onset Generalized

4 (0.28%)

0 (0.00%)

7 (0.42%)

1 (0.24%)

7 (0.41%)

1 (0.20%)

Onset Limbs

983 (68.65%)

238 (68.79%)

1154 (68.73%)

287 (68.01%)

1136 (66.20%)

326 (67.08%)

C9orf72 normal

896 (62.57%)

229 (66.19%)

1013 (60.33)

274 (64.93)

1025 (69.74)

311 (63.99)

C9orf72 expansion

72 (5.03%)

23 (6.65%)

76 (4.53)

24 (5.69)

81 (4.71)

28 (5.76)

C9orf72 NA

464 (32.40%)

94 (27.16%)

590 (35.14)

124 (29.38)

610 (35.55)

147 (40.25)

ALSFRS-R slope

0.43 [0.24-0.79]

0.41 [0.23-0.80]

0.47 [0.25-0.84]

0.44 [0.24-0.85]

0.49 [0.26-0.88]

0.45 [0.24-0.85]

ALSFRS-R recorded

3.0 [2.0–3.0]

3.0 [2.0-3.0]

2.0 [2.0–3.0]

2.0 [2.0–3.0]

2.0 [2.0–3.0]

2.0 [2.0–3.0]

Outcome time

18.07 [11.43–31.33]

20.82 [11.47–36.94]

20.43 [12.87–37.12]

22.47 [13.30–38.59]

23.07 [14.16–39.13]

25.20 [14.62–42.47]

Outcome censoring

121 (8.45%)

32 (9.25%)

209 (12.45%)

51 (12.09%)

230 (13.40%)

69 (14.20%)

Outcome death

636 (44.41%)

152 (43.93%)

969 (57.71%)

251 (59.48%)

1486 (86.60%)

417 (85.80%)

Outcome target

675 (47.14%)

162 (46.82%)

501 (29.84%)

120 (28.44%)