Abstract
Osteoporotic fractures (OPF) and hypertension frequently co-occur in older adults, yet comprehensive datasets integrating clinical, pharmacological, and longitudinal outcome data remain scarce. We describe a longitudinal dataset derived from the Osteoporotic Fracture Registration System at Kunshan Hospital, Jiangsu University, including patients aged ≥ 50 years hospitalized for OPF between 2017 and 2024. A total of 4,782 patients were initially registered. After applying predefined eligibility criteria, 4,325 patients were included in the final analytical cohort. The dataset integrates demographic, clinical, and pharmacologic variables with long-term outcomes on mortality and refracture through deterministic linkage with regional health and mortality registries. Longitudinal antihypertensive prescription records (n = 42,367) were linked via the Kunshan Municipal Health Data Integration Platform, enabling detailed characterization of medication exposure patterns over time. Technical validation, including survival analysis, propensity score methods, and risk prediction modeling, was conducted to assess internal consistency and illustrate potential applications. This structured and de-identified dataset provides a quality-checked resource to support future research in osteoporosis, cardiovascular comorbidity, multimorbidity, and real-world comparative effectiveness studies.
Similar content being viewed by others
Data availability
The dataset described in this study is openly available on Figshare at https://doi.org/10.6084/m9.figshare.30971476.
Code availability
All custom R scripts used for data curation, preprocessing, statistical analysis, technical validation, and figure generation are publicly available in a GitHub repository at https://github.com/LiwenSu0625/hypertensive-osteoporotic-fracture.
References
Hampson, G., Stone, M., Lindsay, J. R., Crowley, R. K. & Ralston, S. H. Diagnosis and management of osteoporosis during COVID-19: systematic review and practical guidance. Calcif. Tissue Int. 109, 351–362 (2021).
Pisani, P. et al. Major osteoporotic fragility fractures: risk factor updates and societal impact. World J. Orthop. 7, 171–181 (2016).
Gonzalez-Marcos, E. et al. Determinants of higher mortality at six months in patients with hip fracture: a retrospective study. J. Clin. Med. 11, 2414 (2022).
Balasubramanian, A. et al. Risk of subsequent fracture after prior fracture among older women. Osteoporos. Int. 30, 79–92 (2019).
Oliveros, E. et al. Hypertension in older adults: assessment, management, and challenges. Clin. Cardiol. 43, 99–107 (2020).
Chen, X., He, B., Zhou, Y., Zhang, X. & Zhao, L. Investigating the effect of history of fractures and hypertension on the risk of all-cause death from osteoporosis: a retrospective cohort study. Medicine (Baltimore) 102, e33342 (2023).
Chen, Y. N., Wei, P. & Yu, B. S. J. Higher concentration of serum C-terminal cross-linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H-type hypertension and osteoporosis. Orthop. Surg. 11, 1135–1141 (2019).
Huang, Y. & Ye, J. Association between hypertension and osteoporosis: a population-based cross-sectional study. BMC Musculoskelet. Disord. 25, 434 (2024).
Fan, Z. et al. Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-alpha expression in macrophages. Front. Endocrinol. (Lausanne) 14, 1207502 (2023).
Al-Ahmari, A. K. Prevalence of hypertension and its associated risk factors among patients with rheumatoid arthritis in the Kingdom of Saudi Arabia. Int. J. Gen. Med. 15, 6507–6517 (2022).
Khinda, R. et al. Prevalence and predictors of osteoporosis and osteopenia in postmenopausal women of Punjab, India. Int. J. Environ. Res. Public Health 19 (2022).
Nakayama, M. et al. Factors associated with osteoporosis medication use in Japanese patients with rheumatoid arthritis: Results from the Institute of Rheumatology Rheumatoid Arthritis cohort study. Osteoporos. Sarcopenia 6, 82–87 (2020).
Abe, K. et al. Deaths caused by osteoporotic fractures in Japan: An epidemiological study. J. Orthop. Sci. 29, 1477–1482 (2024).
Guzon-Illescas, O. et al. Mortality after osteoporotic hip fracture: Incidence, trends, and associated factors. J. Orthop. Surg. Res. 14, 203 (2019).
Xia, P., Jiang, Y., Cai, F., Peng, S. & Xu, Z. Construction and verification of risk prediction model of osteoporotic fractures in patients with osteoporosis in China. Front. Public Health 12, 1380218 (2024).
Puttnam, R. et al. Association of 3 different antihypertensive medications with hip and pelvic fracture risk in older adults: Secondary analysis of a randomized clinical trial. JAMA Intern. Med. 177, 67–76 (2017).
Wei, J. et al. Comparison of cardiovascular events among users of different classes of antihypertension medications: A systematic review and network meta-analysis. JAMA Netw. Open 3, e1921618 (2020).
Osteoporosis Group of Chinese Society of Orthopaedics (OGoCSoO). Guideline on diagnosis and treatment of osteoporotic fractures. Chin. J. Orthop. 37, 1–10 (2017).
Leslie, W. D. et al. Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study. Osteoporos Int. 31, 1059–1067 (2020).
Carey, R. M., Wright, J. T., Taler, S. J. & Whelton, P. K. Guideline-driven management of hypertension: An evidence-based update. Circ. Res. 128, 827–846 (2021).
Böhm, M. et al. Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120–140 mmHg) and cardiovascular outcomes in high-risk patients: Results from ONTARGET and TRANSCEND trials. Eur. Heart J. 39, 3105–3114 (2018).
Charlson, M. E., Pompei, P., Ales, K. L. & MacKenzie, C. R. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J. Chronic Dis. 40, 373–383 (1987).
Lu, K. A longitudinal clinical and prescription dataset of hypertensive osteoporotic fracture patients. Figshare https://doi.org/10.6084/m9.figshare.30971476 (2025).
De Vecchis, R., Ariano, C., Di Biase, G. & Noutsias, M. Thiazides and osteoporotic spinal fractures: A suspected linkage investigated by means of a two-center, case-control study. J. Clin. Med. Res. 9, 943–949 (2017).
Wang, J., Su, K., Sang, W., Li, L. & Ma, S. Thiazide diuretics and the incidence of osteoporotic fracture: A systematic review and meta-analysis of cohort studies. Front. Pharmacol. 10, 1364 (2019).
Lin, S. M., Yang, S. H., Cheng, H. Y., Liang, C. C. & Huang, H. K. Thiazide diuretics and the risk of hip fracture after stroke: A population-based propensity-matched cohort study using Taiwan’s National Health Insurance Research Database. BMJ Open 7, e016992 (2017).
Hargrove, J. L. et al. Initiation of antihypertensive monotherapy and incident fractures among Medicare beneficiaries. Inj. Epidemiol. 4, 27 (2017).
Tinetti, M. E. et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern. Med. 174, 588–595 (2014).
Acknowledgements
The study was supported by National Natural Science Foundation of China (82172441), Suzhou MunicipalScience and Technology Development Plan (Construction of Key Municipal Laboratories) (SZS2024018), SuzhouCity Major Disease Multicenter Clinical Research Project (DZXYJ202312), Special Funding for Jiangsu ProvinceScience and Technology Plan (Key Research and Development Program for Social Development) (BE2023738)and Gusu Health Talent Plan Scientific Research Project (GSWS2022105).
Author information
Authors and Affiliations
Contributions
Chong Li has been involved in conceptualization, data curation, formal analysis, investigation, methodology, visualization, writing, and editing; Li-wen Su and Peng Zhou have contributed to data curation, analysis, methodology, and reviewing; Guo-ji Lin and Jia-qi Liang have been part of data collection, analysis, and manuscript reviewing; Ya-qin Gong has contributed to the methodology, data validation, and reviewing; Jian Jin has provided technical support and manuscript editing; Ke Lu and Wen-rong Xu, as the corresponding authors, have been responsible for project supervision, funding acquisition, manuscript reviewing, and final approval. All authors have read and approved the final manuscript.
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
About this article
Cite this article
Li, C., Lu, K., Su, Lw. et al. A longitudinal dataset of hypertensive osteoporotic fracture patients: treatments and long-term outcomes. Sci Data (2026). https://doi.org/10.1038/s41597-026-07031-7
Received:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41597-026-07031-7
