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Chromosome-level genomes of hard clams Meretrix lamarckii (Deshayes, 1853) and Meretrix meretrix (Linnaeus, 1758)
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  • Published: 27 March 2026

Chromosome-level genomes of hard clams Meretrix lamarckii (Deshayes, 1853) and Meretrix meretrix (Linnaeus, 1758)

  • Sean Tsz Sum Law  ORCID: orcid.org/0000-0003-2613-11081 na1,
  • Wenyan Nong1 na1,
  • Ming Fung Franco Au1,
  • Leni Hiu Tung Cheung1,
  • Cheryl Wood Yee Shum1,
  • Shing Yip Lee2,
  • Siu Gin Cheung3 &
  • …
  • Jerome Ho Lam Hui  ORCID: orcid.org/0000-0003-1355-84951 

Scientific Data , Article number:  (2026) Cite this article

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We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Subjects

  • Evolution
  • Zoology

Abstract

The genus Meretrix contains marine bivalve molluscs commonly known as the Venus clams or hard clams, which can be found in the estuarine and marine habitats in Asia. Given their edibility, they have been exploited in clam digging activities and also been farmed in some places. Here, we provide two new high-quality genomes of species M. meretrix and M. lamarckii. Utilising a combination of PacBio HiFi and Omni-C sequencing technologies, genome assemblies of M. meretrix and M. lamarcki are obtained with sizes 835.1 Mb (scaffold N50 = 46 Mb) and 890.5 Mb (scaffold N50 = 46 Mb), respectively. More than 99% of sequences were anchored to 19 pseudochromosomes, and high completeness was also obtained estimated by BUSCO scores (~99.5%, mollusca_odb12). The two new genomic resources provided in this study will be useful for further understanding biology, ecology, and evolution of edible clams.

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Data availability

The genome assemblies of M. meretrix and M. lamarcki are available at NCBI/ENA GenBank under accessions JBTXPG000000000 and JBTORC000000000, DDBJ accessions PRJDB40269 and PRJDB40270, NGDC accessions GWHHOJO00000000 and GWHHOOY00000000, and CUHK Research Data Repository (https://doi.org/10.48668/DOVLYS), respectively. The raw sequencing data of M. meretrix and M. lamarcki are deposited in the NCBI/ENA database under the SRA accession numbers SRP617717 and SRP618173, DDBJ database under the DRA accession numbers DRR911404-DRR911405 and DRR911157-DRR911158, NGDC database under the GSA accession numbers CRA039134 and CRA039136, and CUHK Research Data Repository (https://doi.org/10.48668/DOVLYS), respectively. The genome annotation files of M. meretrix and M. lamarckii can be found at CUHK Research Data Repository (https://doi.org/10.48668/DOVLYS).

Code availability

No specific script was used in this work.

References

  1. Srinun, N., Vidthayanon, C. & Klangnurak, W. Morphological and genetic variations of Meretrix spp. (Bivalvia: Veneridae) recently distributed in the coastal waters of the Gulf of Thailand. Estuar. Coast. Shelf Sci. 307, 108889 (2024).

    Google Scholar 

  2. Soon, T. K., Sing, O. F., Denil, D. J. & Ransangan, J. Distribution and fishing pressure of hard clam, Meretrix meretrix in Marudu Bay, Sabah. Int. J. Oceans Oceanogr. 11 (2017).

  3. Ye, Y. et al. Genetic Population Structure of the Hard Clam Meretrix meretrix Along the Chinese Coastlines Revealed by Microsatellite DNA Markers. Front. Mar. Sci. 7 (2020).

  4. Chen, Y. et al. The biological resources survey of mudflat clams and other major creatures in Panjin Geligang and Xiao He. Hebei Fish 1, 46–49 (2012).

    Google Scholar 

  5. So, K. J. Y., Cheang, C. C., Hui, T. Y. & Chan, J. K. Y. Understanding the behavioural gap between perceived and actual environmental behaviour: Investigating the clam-harvesting pattern in Hong Kong SAR, China. J. Clean. Prod. 316, 128259 (2021).

    Google Scholar 

  6. WoRMS. World Register of Marine Species. https://www.marinespecies.org, https://doi.org/10.14284/170 (2025).

  7. Chen, C.-C., Hsu, T.-H., Lu, H.-Y., Tang, S.-L. & Ho, Y.-N. High-quality chromosome-level genome of three Meretrix species using Nanopore and Hi-C technologies. Sci. Data 12, 1141 (2025).

    Google Scholar 

  8. Morton, B., Leung, S. F. & Leung, K. F. The biology and functional morphology of Meretrix cf. meretrix (Bivalvia: Veneridae: Meretricinae) at Tong Fuk Miu Wan, Shui Hau, Lantau Island, Hong Kong. Reg. Stud. Mar. Sci. 45, 101842 (2021).

    Google Scholar 

  9. Hsiao, S.-T. & Chuang, S.-C. Meretrix taiwanica (Bivalvia: Veneridae), a previously misidentified new species in Taiwan. Molluscan Res. 43, 12–21 (2023).

    Google Scholar 

  10. Law, S. T. S. et al. Genomes of two indigenous clams Anomalocardia flexuosa (Linnaeus, 1767) and Meretrix petechialis (Lamarck, 1818). Sci. Data 12, 409 (2025).

    Google Scholar 

  11. Folmer, O., Black, M., Hoeh, W., Lutz, R. & Vrijenhoek, R. DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. Mol. Mar. Biol. Biotechnol. 3, 294–299 (1994).

    Google Scholar 

  12. Chen, J., Li, Q., Kong, L. & Zheng, X. Molecular phylogeny of venus clams (Mollusca, Bivalvia, Veneridae) with emphasis on the systematic position of taxa along the coast of mainland China. Zool. Scr. 40, 260–271 (2011).

    Google Scholar 

  13. Wang, X., Kong, L., Chen, J., Matsukuma, A. & Li, Q. Phylogeography of bivalve Meretrix petechialis in the Northwestern Pacific indicated by mitochondrial and nuclear DNA data. PLOS ONE 12, e0183221 (2017).

    Google Scholar 

  14. Zhang, S. P., Wang, H. X. & Xu, F. S. Taxonomic study on Meretrix (Bivalvia, Veneridae) from China seas. Acta Zootaxononomica Sin. 37 (2012).

  15. Katoh, K. & Standley, D. M. MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability. Mol. Biol. Evol. 30, 772–780 (2013).

    Google Scholar 

  16. Price, M. N., Dehal, P. S. & Arkin, A. P. FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments. PLOS ONE 5, e9490 (2010).

    Google Scholar 

  17. Cheng, H., Concepcion, G. T., Feng, X., Zhang, H. & Li, H. Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm. Nat. Methods 18, 170–175 (2021).

    Google Scholar 

  18. Guan, D. et al. Identifying and removing haplotypic duplication in primary genome assemblies. Bioinformatics 36, 2896–2898 (2020).

    Google Scholar 

  19. Laetsch, D. R. & Blaxter, M. L. BlobTools: Interrogation of genome assemblies. Preprint at https://doi.org/10.12688/f1000research.12232.1 (2017).

  20. Zhou, C., McCarthy, S. A. & Durbin, R. YaHS: yet another Hi-C scaffolding tool. Bioinformatics 39, btac808 (2023).

    Google Scholar 

  21. Durand, N. C. et al. Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom. Cell Syst. 3, 99–101 (2016).

    Google Scholar 

  22. Astashyn, A. et al. Rapid and sensitive detection of genome contamination at scale with FCS-GX. Genome Biol. 25, 60 (2024).

    Google Scholar 

  23. Hoff, K. J., Lomsadze, A., Borodovsky, M. & Stanke, M. Whole-Genome Annotation with BRAKER. in Gene Prediction: Methods and Protocols (ed. Kollmar, M.) 65–95. https://doi.org/10.1007/978-1-4939-9173-0_5 (Springer, New York, NY, 2019).

  24. Stanke, M., Diekhans, M., Baertsch, R. & Haussler, D. Using native and syntenically mapped cDNA alignments to improve de novo gene finding. Bioinformatics 24, 637–644 (2008).

    Google Scholar 

  25. Baril, T., Galbraith, J. & Hayward, A. Earl Grey: A Fully Automated User-Friendly Transposable Element Annotation and Analysis Pipeline. Mol. Biol. Evol. 41, msae068 (2024).

    Google Scholar 

  26. Emms, D. M. & Kelly, S. OrthoFinder: phylogenetic orthology inference for comparative genomics. Genome Biol. 20, 238 (2019).

    Google Scholar 

  27. Wei, M. et al. Chromosome-Level Clam Genome Helps Elucidate the Molecular Basis of Adaptation to a Buried Lifestyle. iScience 23, 101148 (2020).

    Google Scholar 

  28. Song, H. et al. The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia. BMC Biol. 19, 15 (2021).

    Google Scholar 

  29. McCartney, M. A. et al. The genome of the zebra mussel, Dreissena polymorpha: a resource for comparative genomics, invasion genetics, and biocontrol. G3 GenesGenomesGenetics 12, jkab423 (2022).

    Google Scholar 

  30. Li, J. et al. Chromosome-level genome assembly and annotation of rare and endangered tropical bivalve, Tridacna crocea. Sci. Data 11, 186 (2024).

    Google Scholar 

  31. Guo, Y. et al. Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves. BMC Biol. 21, 51 (2023).

    Google Scholar 

  32. Bai, Y. et al. Multi-omic insights into the formation and evolution of a novel shell microstructure in oysters. BMC Biol. 21, 204 (2023).

    Google Scholar 

  33. Regan, T., Hori, T. S. & Bean, T. P. A chromosome-scale Mytilus edulis genome assembly for aquaculture, marine ecology, and evolution. G3 GenesGenomesGenetics 14, jkae138 (2024).

    Google Scholar 

  34. McElroy, K. E., Masonbrink, R., Chudalayandi, S., Severin, A. J. & Serb, J. M. A chromosome-level genome assembly of the disco clam, Ctenoides ales. G3 GenesGenomesGenetics 14, jkae115 (2024).

    Google Scholar 

  35. Sanderson, M. J. r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Bioinformatics 19, 301–302 (2003).

    Google Scholar 

  36. Hedges, S. B., Dudley, J. & Kumar, S. TimeTree: a public knowledge-base of divergence times among organisms. Bioinformatics 22, 2971–2972 (2006).

    Google Scholar 

  37. Manni, M., Berkeley, M. R., Seppey, M. & Zdobnov, E. M. BUSCO: Assessing Genomic Data Quality and Beyond. Curr. Protoc. 1, e323 (2021).

    Google Scholar 

  38. Lovell, J. T. et al. GENESPACE tracks regions of interest and gene copy number variation across multiple genomes. eLife 11, e78526 (2022).

    Google Scholar 

  39. Wang, Y. et al. MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity. Nucleic Acids Res. 40, e49 (2012).

    Google Scholar 

  40. Li, H. Minimap2: pairwise alignment for nucleotide sequences. Bioinformatics 34, 3094–3100 (2018).

    Google Scholar 

  41. Robinson, J. T., Thorvaldsdottir, H., Turner, D. & Mesirov, J. P. igv.js: an embeddable JavaScript implementation of the Integrative Genomics Viewer (IGV). Bioinformatics 39, btac830 (2023).

    Google Scholar 

  42. NCBI GenBank https://identifiers.org/ncbi/insdc:JBTXPG000000000 (2026).

  43. European Nucleotide Archive https://www.ebi.ac.uk/ena/browser/view/GCA_055551385.1 (2026).

  44. NCBI GenBank https://identifiers.org/ncbi/insdc:JBTORC000000000 (2026).

  45. European Nucleotide Archive https://www.ebi.ac.uk/ena/browser/view/GCA_055550865.1 (2026).

  46. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/bioproject/PRJDB40269 (2026).

  47. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/bioproject/PRJDB40270 (2026).

  48. National Genomics Data Center https://ngdc.cncb.ac.cn/gwh/Assembly/111533/show (2026).

  49. National Genomics Data Center https://ngdc.cncb.ac.cn/gwh/Assembly/111604/show (2026).

  50. Law, S. T. S. et al. Chromosome-level genomes of hard clams Meretrix lamarckii (Deshayes, 1853) and Meretrix meretrix (Linnaeus, 1758). CUHK Research Data Repository https://doi.org/10.48668/DOVLYS (2025).

    Google Scholar 

  51. NCBI Sequence Read Archive https://identifiers.org/ncbi/insdc.sra:SRP617717 (2026).

  52. European Nucleotide Archive https://www.ebi.ac.uk/ena/browser/view/PRJNA1312090 (2026).

  53. NCBI Sequence Read Archive https://identifiers.org/ncbi/insdc.sra:SRP618173 (2026).

  54. European Nucleotide Archive https://www.ebi.ac.uk/ena/browser/view/PRJNA1315236 (2026).

  55. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/sra-run/DRR911404 (2026).

  56. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/sra-run/DRR911405 (2026).

  57. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/sra-run/DRR911157 (2026).

  58. DNA Data Bank of Japan https://ddbj.nig.ac.jp/search/entry/sra-run/DRR911158 (2026).

  59. National Genomics Data Center https://ngdc.cncb.ac.cn/gsa/browse/CRA039134 (2026).

  60. National Genomics Data Center https://ngdc.cncb.ac.cn/gsa/browse/CRA039136 (2026).

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Acknowledgements

This work was supported by Lantau Conservation Fund (RE-2020-39), Hong Kong Research Grant Council Collaborative Research Fund (C4015-20EF), Innovation Technology Fund of Innovation Technology Commission: Funding Support to State Key Laboratory of Agrobiotechnology, and Direct Grant of The Chinese University of Hong Kong.

Author information

Author notes
  1. These authors contributed equally: Sean Tsz Sum Law, Wenyan Nong.

Authors and Affiliations

  1. School of Life Sciences, Simon F.S. Li Marine Science Laboratory, Institute of Environment, Energy and Sustainability, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong SAR, China

    Sean Tsz Sum Law, Wenyan Nong, Ming Fung Franco Au, Leni Hiu Tung Cheung, Cheryl Wood Yee Shum & Jerome Ho Lam Hui

  2. Simon F.S. Li Marine Science Laboratory, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Australian Rivers Institute, Griffith University Gold Coast campus, Southport, Qld, 4222, Australia

    Shing Yip Lee

  3. Department of Chemistry, State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong SAR, China

    Siu Gin Cheung

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Contributions

S.Y.L., S.G.C. and J.H.L.H. conceived and supervised the study; S.T.S.L., M.F.F.A., L.H.T.C. and C.W.Y.S. carried out sample collection; S.T.S.L. and W.N. performed data curation on the analysis; J.H.L.H. and S.T.S.L. wrote the initial manuscript; all authors revised and contributed to the final version of the manuscript.

Corresponding authors

Correspondence to Shing Yip Lee, Siu Gin Cheung or Jerome Ho Lam Hui.

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Law, S.T.S., Nong, W., Au, M.F.F. et al. Chromosome-level genomes of hard clams Meretrix lamarckii (Deshayes, 1853) and Meretrix meretrix (Linnaeus, 1758). Sci Data (2026). https://doi.org/10.1038/s41597-026-07119-0

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  • Received: 18 September 2025

  • Accepted: 19 March 2026

  • Published: 27 March 2026

  • DOI: https://doi.org/10.1038/s41597-026-07119-0

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