Figure 3
Landscape of somatic variable sites in AOM/DSS mouse model and its comparisons with Human CRC. (A) Numbers of somatic SNVs and InDels in each of 14 neoplastic samples. (B) The ratio of SNVs to InDels in the total somatic variable sites is showed with pie plot. (C) Relative proportion of the six mutational spectra in each neoplastic sample. (D) The proportion of six mutational spectra in the total somatic variable sites is showed with pie plot. (E) Relative proportion of somatic variants in each of six functional regions as indicated in the legend box in each of samples. (F) Proportions of total somatic mutations (blue) and capture-targeting sites (red) in six functional regions. (G) Percentage values of sample-unique somatic variable sites and non-sample-unique somatic variable sites in group 7A, 7T, 10T and total of 14 neoplastic samples. (H) Box plot shows the range of mutation rates in three groups of human CRC and AOM/DSS mice. (I) Percentage values of six mutational spectra in three groups of human CRC and AOM/DSS mice. (J) Frequents of the top 20 most frequently mutated sites in human CRC reported by TCGA in three groups of human CRC and AOM/DSS mice. In Fig. 3H, (I and J), three groups of human CRC, Total, MSS and MSI, are indicated with blue, green and sky blue, respectively. The group of AOM/DSS mice is indicated with red.
