Figure 4
Landscape of somatic mutant genes in AOM/DSS mouse model and its comparisons with Human CRC. (A) Number of somatic mutant genes in each of 14 neoplastic samples are indicated with bar plot. The recurrent SMGs (P-value < 0.01 and Q-value < 0.1) identified in AOM/DSS mouse model are listed vertically by frequent and Q-value. A heat map, in which a red square indicated mutation of specific SMG in corresponding sample, show the distribution of such SMGs in 14 neoplastic samples. By the left, the frequent of individuals with mutations of each gene is shown with bar plot, while by the right is the Q-value of each SMG. Another heat map in the upper right corner shows the mutational profiling of nine MMR genes in AOM/DSS mouse model. (B) Percentage values of sample-unique somatic mutant genes and non-sample-unique somatic mutant genes in group 7A, 7T, 10T and total of 14 neoplastic samples. (C) Mapping of somatic mutations in four cancer-related SMGs, MUC4, PHF5A, STUB1 and EDARADD. (D) Frequencies of the 30 SMGs of human CRC reported by TCGA in three groups of human CRC and AOM/DSS mice. Three groups of human CRC, Total, MSS and MSI, are indicated with blue, green and sky blue, respectively, while the group of AOM/DSS mice is indicated with red.
