Figure 3 | Scientific Reports

Figure 3

From: Hydrolysis of Hyaluronic Acid in Lymphedematous Tissue Alleviates Fibrogenesis via TH1 Cell-Mediated Cytokine Expression

Figure 3

Hyaluronidase treatment restores dilated lymphatic vessels to round lymphatic vessels and downregulates the expression of fibrosis markers. Histological analysis of the effects of hyaluronidase on fibrosis in lymphedema. (A,B) Immunofluorescence staining of LYVE-1, VEGFR-3, and alpha-smooth muscle actin in proximal mouse leg sections. Scale bar = 100 μm. Regions of LTVE-1 and VEGFR-3 colocalization in the lymphatic vessels are marked with yellow arrows. (C,D) Immunohistochemistry analysis of RAC1 and CTGF in the dermis layer of the mouse leg. Scale bar = 500 μm.

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