Figure 4 | Scientific Reports

Figure 4

From: Hydrolysis of Hyaluronic Acid in Lymphedematous Tissue Alleviates Fibrogenesis via TH1 Cell-Mediated Cytokine Expression

Figure 4

Hyaluronidase injection induces anti-fibrotic responses. Molecular analysis of mouse leg lysates. (A–C) Quantitative real-time PCR analysis of VEGF-D, fibronectin, MMP3, MMP9, α-SMA and HABP2. (A) Increased expression levels of MMP3 and MMP9 were observed, (B) Whereas decreased expression levels of VEGF-D, and fibronectin were observed in the hyaluronidase-injected mice. (C) The expression of α-SMA was decreased with hyaluronidase treatment, but HABP2 expression was increased. Data are presented as means ± SEMs. *P < 0.05, ***P < 0.001.

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