Figure 8
Total plasma concentrations, calculated and simulated target occupancy. (a) Observed plasma concentrations (dots), linear fit of the data (line) and 95% confidence interval of the linear regression (shaded area). (b) Equilibrium occupancy derived from the experimentally observed plasma concentrations (dots) and simulated occupancy on basis of the observed binding kinetics and plasma elimination rate (line). Graphs shown are representative from one experiment (n = 3 per time point).
