Table 2 Main enzymatic and metabolic pathways associated with the up-regulated and down-regulated proteins in ganetespib-treated 5637 cells as analyzed by the Kyoto Encyclopedia of Genes and Genomes (KEGG).
Biological pathway | % | P-value |
|---|---|---|
≥Twofold up-regulated proteins | ||
Steroid biosynthesis | 0.7 | 2.3 × 10−4 |
Regulation of actin cytoskeleton | 2.7 | 4.3 × 10−4 |
Ubiquitin mediated proteolysis | 2.1 | 1.1 × 10−3 |
Endocytosis | 2.2 | 1.6 × 10−3 |
Adherens junction | 1.2 | 3.8 × 10−3 |
N-Glycan biosynthesis | 0.8 | 1.4 × 10−2 |
SNARE interactions in vesicular transport | 0.8 | 1.5 × 10−2 |
Valine, leucine and isoleucine biosynthesis | 0.4 | 2.1 × 10−2 |
Phosphatidylinositol signaling system | 1.0 | 2.3 × 10−2 |
ErbB signaling pathway | 1.1 | 2.5 × 10−2 |
Inositol phosphate metabolism | 0.8 | 3.1 × 10−2 |
Terpenoid backbone biosynthesis | 0.4 | 4.9 × 10−2 |
Pantothenate and CoA biosynthesis | 0.4 | 4.9 × 10−2 |
≥Twofold down-regulated proteins | ||
Oxidative phosphorylation | 2.5 | 1.1 × 10−8 |
Pyrimidine metabolism | 2.1 | 3.8 × 10−8 |
Purine metabolism | 2.2 | 4.6 × 10−5 |
Notch signaling pathway | 1.0 | 1.3 × 10−4 |
RNA polymerase | 0.8 | 1.9 × 10−4 |
Spliceosome | 1.8 | 2.7 × 10−4 |
Basal transcription factors | 0.6 | 2.1 × 10−2 |
Pathways in cancer | 2.7 | 2.6 × 10−2 |
Cell cycle | 1.3 | 3.4 × 10−2 |
Glutathione metabolism | 0.7 | 3.9 × 10−2 |
Nucleotide excision repair | 0.6 | 4.3 × 10−2 |
Bladder cancer | 0.6 | 4.8 × 10−2 |
DNA replication | 0.6 | 4.9 × 10−2 |
