Table 3 Esophageal toxicity prediction for four Des.

From: Different definitions of esophagus influence esophageal toxicity prediction for esophageal cancer patients administered simultaneous integrated boost versus standard-dose radiation therapy

Strategy

Parameters

ESOwhole

ESOinfield

ESOinfield-tumor

ESOwhole-tumor

p

p 1

p 2

SIB-IMRT

Kwint (%)a

75.1 ± 5.7

87.9 ± 1.5

83.3 ± 3.5

59.2 ± 4.2

N/A

N/A

N/A

Kwint (%)b

37.2 ± 8.7

61.0 ± 3.8

50.0 ± 6.9

19.2 ± 3.2

N/A

N/A

N/A

Wijsman (%)c

63.5 ± 13.6

90.8 ± 2.5

80.7 ± 6.1

30.2 ± 7.7

N/A

N/A

N/A

Chen (%)d

(1.5 ± 1.0) × 10−1

(3.9 ± 1.6) × 10−1

(1.2 ± 2.8) × 10−2

(1.5 ± 5.0) × 10−3

N/A

N/A

N/A

SD-IMRT

Kwint (%)a

72.2 ± 5.8

84.8 ± 2.1

81.1 ± 3.9

57.7 ± 4.2

N/A

N/A

N/A

Kwint (%)b

32.9 ± 7.7

53.8 ± 4.7

45.8 ± 7.0

18.0 ± 2.9

N/A

N/A

N/A

Wijsman (%)c

48.8 ± 10.7

77.6 ± 2.7

73.5 ± 5.8

26.8 ± 6.6

N/A

N/A

N/A

Chen (%)d

(1.7 ± 1.7) × 10−23

(1.4 ± 1.2) × 10−22

(8.1 ± 5.3) × 10−23

(6.8 ± 6.0) × 10−25

N/A

N/A

N/A

SIB-SD

Kwint (%)a

2.9 ± 1.6

3.1 ± 1.8

2.2 ± 1.4

1.6 ± 1.0

0.000

0.002

0.048

Kwint (%)b

4.3 ± 2.7

7.2 ± 3.8

4.2 ± 2.8

1.2 ± 0.9

0.000

0.000

0.008

Wijsman (%)c

14.6 ± 3.1

13.2 ± 1.0

7.2 ± 1.2

3.4 ± 1.2

0.000

0.000

0.000

Chen (%)d

(1.5 ± 1.0) × 10−1

(3.9 ± 1.6) × 10−1

(1.2 ± 2.8) × 10−2

(1.5 ± 5.0) × 10−3

0.000

0.000

0.000

  1. Abbreviations: SIB-IMRT = intensity-modulated radiation therapy with simultaneous integrated boost; SD-IMRT = standard-dose intensity-modulated radiation therapy; SIB-SD = the difference in predicting value between the SIB-IMRT and SD-IMRT plans; ESOwhole = the entire esophagus, including the tumor; ESOinfield = the portion of ESOwhole within the treatment field; ESOinfield-tumor = the portion of ESOinfield, excluding the tumor; ESOwhole-tumor = the portion of ESOwhole, excluding the tumor. Kwint = Kwint model; Wijsman = Wijsman model; Chen = Chen model. N/A = not available. p 1: ESOwhole vs. ESOwhole-tumor; p 2 ESOinfield vs. ESOinfield-tumor.
  2. aIndicates Kwint model for predicting grade ≥ 2 acute esophageal toxicity.
  3. bIndicates Kwint model for predicting grade ≥ 3 acute esophageal toxicity.
  4. cIndicates Wijsman model for predicting grade ≥ 2 acute esophageal toxicity.
  5. dIndicates Chen model for predicting late esophageal toxicity.
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