Figure 3 | Scientific Reports

Figure 3

From: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis

Figure 3

Transcriptional activity of different CCR5 promoter haplotypes. (A) 293 T cells were transfected with plasmid DNA containing CCR5 gene promoter haplotype (HHA, HHB, HHC, HHD, HHE, HHF and HHG) upstream of the luciferase gene. Promoter activity was determined 48 h later by measuring luciferase activity in cell lysates. Data was normalized to HHA, the ancestral haplotype. Bars represent mean ± SD of triplicate observations from 4 independent experiments. (B) Relative promoter activity (RPA) of each CCR5 promoter haplotype after normalizing to the ancestral allele HHA.

Back to article page