Figure 4 | Scientific Reports

Figure 4

From: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis

Figure 4

Combined CCR5 relative promoter activity (CRPA) of both alleles in HIV patients correlates with CD4 counts. Each patient was assigned a numerical CRPA score based on the RPA of both alleles. The patient population was then divided into two groups of CRPA > 229 or CRPA < 229. CD4 counts in CRPA > 229 vs CRPA < 229 in (A) all HIV+ patients (B) viremic patients. CD4:CD8 ratio in CRPA > 229 vs CRPA < 229 in (C) all HIV+ patients (D) viremic patients. CD8 immune activation in CRPA > 229 vs CRPA < 229 in (E) all HIV+ patients (F) viremic patients. CD4 apoptosis in CRPA > 229 vs CRPA < 229 in (G) all HIV+ patients (H) viremic patients. (I) CD4 apoptosis in CRPA > 229 vs CRPA < 229 no HHG2 (after removing one data point from an HHG2 patient). Log viremia in CRPA > 229 vs CRPA < 229 in (J) all HIV+ or (K) viremic patients. One tailed student's t-test was used for statistical analysis.

Back to article page