Figure 8 | Scientific Reports

Figure 8

From: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis

Figure 8

Model of HIV pathogenesis proposing a role of Env glycoprotein phenotype (AIP), viremia, immune activation and CCR5 levels in collectively determining CD4 bystander apoptosis. The model incorporates CCR5 levels at the center as a major factor which may regulate both plasma viral load and apoptosis mediated by Env glycoprotein leading to CD4 decline.

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