Figure 2

Bisulfite sequencing of mtDNA. Bisulfite sequencing of a region in the D-loop (H-strand) (a) and mtCOX2 gene (L-strand) (b) for SKOV3, skin fibroblasts of a mtDNA disease patient (only in a) HeLa, HCT116 and C33A cells (a,b). Each circle represents a single CpG position, the percentage of black of each circle represents the percentage of methylation.