Figure 4
From: MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response
MKL1 deficiency cripples inflammatory response in mice. (A) C57/BL6 mice were injected with LPS (25 mg/kg). Peritoneal macrophages were isolated 6 hours after injection and ChIP assays were performed with anti-MKL1. (B,C) Sex- and age-matched WT and MKL1 KO male mice were injected with LPS (25 mg/kg). Survival (B) and body temperature (C) were monitored following injection. N = 10 mice for each group. (D–G) Mice were sacrificed 4 hours after injection. Circulating levels of pro-inflammatory mediators were measured by ELISA. N = 6 mice for each group.
