Figure 6
From: MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response
MKL1 influences global H3K4Me3 levels in BMDMs. Wild type (WT) or MKL1 deficient (KO) BMDMs were treated with TNF-α (10 ng/ml) for 3 hours. ChIP was performed with anti-H3K4Me3. (A) Venn diagram illustrating the overlap of binding peaks identified in WT and KO BMBM ChIP-seq data sets. (B) Pathway analysis of significantly enriched H3K4Me3 tags found within ±2 kb relative to the TSS of the nearest gene. (C) Graphical view of H3K4Me3 ChIP-seq binding peaks (tag densities) around the TSS of TNF-α.
