Figure 3
Behavioral recovery was assessed after stroke in young and aged mice. Behavioral recovery in young animals was assessed following 0.3 mg/kg and 1 mg/kg dosing of PEG-IGF-I on both the grid-walking (A and B respectively) and cylinder/forelimb asymmetry (D and E respectively) tasks. Behavioral recovery was also assessed in aged animals following 1 mg/kg dosing of PEG-IGF-I on both the grid-walking (C) and cylinder/forelimb asymmetry (F) tasks. An n = 10 per group were used for these studies. *P < 0.05, **P < 0.01, ***P < 0.001: significance between stroke + vehicle and stroke + PEG-IGF-I-treated from 3 hrs; +P < 0.05: significance between stroke + vehicle and stroke + PEG-IGF-I-treated from 1-day.
