Figure 9
From: Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation
DSP domain regulates dental mesenchymal cell differentiation through occludin-FAK signaling. The hypothetical model depicts that the DSPaa 363–458 acts as a ligand and interacts with the extracellular loop 2 of Oclnaa 194–241, activating Ocln phosphorylation at Ser490. Furthermore, the DSP-Ocln complex activates FAK phosphorylation at Ser722 and Tyr576 and then induces dental mesenchymal cell differentiation and mineralization.
