Table 1 Expression, signaling pathway and function of the four proteins bound by dentin sialoprotein.
From: Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation
gene | Expression feature | Signaling pathway | Relations to human disorder | Interaction molecules |
|---|---|---|---|---|
Collagen IV | The major structural component of glomerular basement membranes | Interleukin-3, 5 and GM-CSF signaling and Pathways in cancer | Alport Syndrome, Autosomal Recessive and Alport Syndrome, Autosomal Dominant | Forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. |
Endoglin | Expressed in endothelial cells, smooth muscle cells, vascular smooth muscle cells | TGF-β Receptor Signaling Pathway | Telangiectasia, Hereditary Hemorrhagic, Type 1 and Hereditary Hemorrhagic Telangiectasia, Tumor angiogenesis, tumor growth and metastasis | Interacted with zyxin, ZRP-1, β-arrestin,Tctex2β, LK1, ALK5, TGFβ II, and GIPC |
Integrin β6 | Proliferating epithelia, esp. lung and mammary gland | ERK, Rho Family, GTPases, MAPK, FAK1 Signaling | Amelogenesis Imperfecta, Type Ih and Hypocalcified Amelogenesis Imperfecta, tumor growth and metastasis | Fibronectin; TGF-β I, dentin sialoprotein |
Occludin | Widely distributed in the epithelial cells and endothelial cells of brain, liver, lung, kidney | VCAM-1/CD106 Signaling Pathways and Blood-Brain Barrier Pathway | Band-Like Calcification With Simplified Gyration and Polymicrogyria | Interact with ZO-1, ZO-2, ZO-3, Claudin and other proteins to form tight junction |
