Table 1 Co-crystallization of aaRSs from SSGCID organisms.
From: Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
Class | aaRS | Organism | TargetDB ID | Ligand | Crystals | Diffraction | Structure |
|---|---|---|---|---|---|---|---|
Ia | ArgRS | Brucella melitensis | BrabA.00164.a | Arg/ATP | ✓ | ✓ | |
Ia | CysRS | Anaplasma phagocytophilum | AnphA.00302.a | Cys/ATP | ✓ | ||
CysRS | Bartonella henselae | BaheA.00133.a | Cys/ATP | ||||
CysRS | Borrelia Burgdorferi | BobuA.00133.a | Cys/ATP | ✓ | ✓ | ✓ | |
CysRS | Brucella melitensis | BrabA.00133.a | Cys/ATP | ||||
CysRS | Burkholderia pseudomallei | BupsA.00133.a | Cys/ATP | ||||
CysRS | Rickettsia prowazekii | RiprA.00133.a | Cys/ATP | ✓ | ✓ | ||
Ia | MetRS | Anaplasma phagocytophilum | AnphA.10201.a | SeMet/ATP | |||
MetRS | Bartonella henselae | BaheA.10201.a | SeMet/ATP | ||||
MetRS | Brucella melitensis | BrabA.10201.a | SeMet/ATP | ✓ | ✓ | ✓ | |
MetRS | Burkholderia pseudomallei | BupsA.10201.a | SeMet/ATP | ||||
Ib | GluRS | Borrelia Burgdorferi | BobuA.01348.a | Glu | ✓ | ✓ | ✓ |
GluRS | Burkholderia thailandensis | ButhA.01187.a | Glu | ✓ | ✓ | ✓ | |
GluRS | Ehrlicia chaffensis | EhchA.01521.a | Glu | ||||
Ic | TrpRS | Anaplasma phagocytophilum | AnphA.00430.a | Trp/ATP | ✓ | ||
TrpRS | Bartonella henselae | BaheA.00241.a | Trp/ATP | ✓ | |||
TrpRS | Encephalitozoon cuniculi | EncuA.00600.a | Trp/ATP | ✓ | ✓ | ✓ | |
Ic | TyrRS | Anaplasma phagocytophilum | AnphA.01028.a | Tyr/ATP | ✓ | ✓ | |
TyrRS | Borrelia Burgdorferi | BobuA.01032.a | Tyr/ATP | ✓ | |||
TyrRS | Encephalitozoon cuniculi | EncuA.00932.a | Tyr/ATP | ✓ | |||
IIa | HisRS | Burkholderia pseudomallei | BupsA.00063.a | His/ATP | ✓ | ||
HisRS | Burkholderia thailandensis | ButhA.00063.a | His/ATP | ✓ | ✓ | ✓ | |
HisRS | Ehrlicia chaffensis | EhchA.00686.a | His/ATP | ||||
IIa | ThrRS | Bartonella henselae | BaheA.10252.a | Borrelidin | |||
ThrRS | Brucella melitensis | BrabA.000156.a | Borrelidin | ||||
ThrRS | Burkholderia pseudomallei | BupsA.00156.a | Borrelidin | ✓ | ✓ | ||
IIb | LysRS | Burkholderia thailandensis | ButhA.00612.a | Lys | ✓ | ✓ | ✓ |
IIc | PheRS | Brucella melitensis | BrabA.00163.a | Phe/ATP | ✓ | ||
PheRS | Mycobacterium abscesus | MyabA.00163.a | Phe/ATP | ||||
PheRS | Mycobacterium marinum | MymaA.00163.a | Phe/ATP | ||||
PheRS | Mycobacterium smegmatis | MysmA.00163.a | Phe/ATP |
