Table 4 Adjusted associations for methylation levels of the 9-CpGs in the DMR of the PON1 gene in cord-blood of males with cognitive test scores measured during early childhood. Estimated change in cognitive test scores per 10% increase in methylation of each CpG and mean methylation levels of the PON1 region.
PON1 CpG ID | PPVT score (N = 135) | WRAVMA total (N = 128) | ||
|---|---|---|---|---|
Cord Blood Methylation | β-Coefficient (95% CI) | P | β-Coefficient (95% CI) | P |
cg07404485 | −2.1 (−3.7, −0.2) | 0.19 | 0.03 (−2.2, 2.2) | 0.97 |
cg05342682 | −3.2 (−6.2, −0.2) | 0.03 | −1.5 (−3.7, 0.6) | 0.15 |
cg04155289 | −0.5 (−2.9, 4.0) | 0.75 | −0.4 (−2.8, 1.9) | 0.72 |
cg19678392 | −2.2 (−4.6, 0.2) | 0.07 | −0.4 (−2.1, 1.3) | 0.64 |
cg21856205 | −4.4 (−8.7, −0.1) | 0.04 | −1.1 (−4.2, 2.0) | 0.48 |
cg17330251 | −1.9 (−3.6, −0.1) | 0.03 | −0.3 (−1.5, 0.9) | 0.64 |
cg01874867 | −2.0 (−3.7, −0.2) | 0.02 | −0.4 (−1.7, 0.8) | 0.48 |
cg20119798 | −2.1 (−5.0, 0.7) | 0.13 | −0.5 (−2.4, 1.5) | 0.64 |
cg04871131 | −2.9 (−9.0, 3.2) | 0.35 | −1.1 (−5.3, 3.2) | 0.62 |
Mean DMR methylation | −2.6 (−5.6, 0.3) | 0.07 | −0.6 (−2.7, 1.4) | 0.55 |
