Figure 5
From: Natural killer cell activation contributes to hepatitis B viral control in a mouse model
Depletion of NK cells abrogates the anti-HBV activity of PolyI:C. Mice were injected with HBV plasmid and chronically treated with control Ab or anti–ASGM-1 Ab and Poly I:C, as described in Materials and Methods, for 5weeks. (A) Depletion of NK cells (NK1.1 + CD3−) was confirmed by flow cytometry. (B) Titers of serum HBsAg were determined at the indicated time points post injection. *p < 0.05 vs. PBS + IgG group or PBS + anti–ASGM-1 group or Poly I:C + anti–ASGM-1 group. (C) Titers of serum HBV DNA copies were determined at 2 weeks post injection. Data are shown as mean ± SEM; *p < 0.05, **p < 0.01. n = 4–6 in each group.
