Figure 3
From: Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
Dose Response Testing of Hits against EPAC1-CNB. The three hit compounds isolated from the Bioascent libraries (structures and molecular weights are shown on the left) were tested in a 7-point dose response format (75 µM top concentration, 1 in 2 serial dilution, n = 6 on one plate) alongside a non-binding compound (I516) in the EPAC1-CNB, 8-NBD-cAMP binding assay with final DMSO concentration of 0.75%. IC50 values are shown in the individual graphs.
