Figure 9
Local FTY720 release recruits biased progenitors of wound healing macrophages to inflamed tissue. Circulating non-classical S1PR3hi monocytes are recruited by local delivery of FTY720 from a material implanted within an injury site. Upon entrance into inflamed tissue, non-classical monocytes give rise to alternatively activated, wound healing macrophages. Conversely, classical monocytes differentiate into both inflammatory and wound healing macrophages.
