Figure 4 | Scientific Reports

Figure 4

From: Reconstruction of Large-scale Defects with a Novel Hybrid Scaffold Made from Poly(L-lactic acid)/Nanohydroxyapatite/Alendronate-loaded Chitosan Microsphere: in vitro and in vivo Studies

Figure 4The alt text for this image may have been generated using AI.

X-ray analysis of bone regeneration at different times after implanting operation. (A) Representative radiographs of bone regeneration at different times. In the control group, there was some new bone formation but the bone defect was not repaired; In autograft group, autologous orthotopic transplantation allowed a complete healing of radius defects during the 8 weeks follow-up; In CM-ALs (0%)-implanted group, there was obvious new bone formation at week 8. The bone fracture lines were scarcely observed, while bone marrow cavities were not found to become interconnected; In CM-ALs (10%)-implanted group, bone defects were healed with new bone formation during 4 to 8 weeks. (B) Semiquantitative analysis showed significant new bone formation in CM-ALs (10%)-implanted group when compared CM-ALs (0%)-implanted group and data increased with time. *p < 0.05 vs the CM-ALs (0%) control group.

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