Figure 5 | Scientific Reports

Figure 5

From: Reconstruction of Large-scale Defects with a Novel Hybrid Scaffold Made from Poly(L-lactic acid)/Nanohydroxyapatite/Alendronate-loaded Chitosan Microsphere: in vitro and in vivo Studies

Figure 5The alt text for this image may have been generated using AI.

Histological analysis of bone regeneration and scaffold degradation at different times after implanting operation. (A) HE staining showing a small amount of newly formed trabeculae at 2 weeks in both CM-ALs (0%) and CM-ALs (10%) groups. At week 4 and 8, coarse bone trabeculae were presented and clustered with the vascular structure clearly seen. The fibrous tissue filled defect was still observable in the CM-ALs (0%) group, while it was less visible in the CM-ALs (10%) group; (B) The quantitative analysis showed the increased new bone area with the incorporated CM-ALs and increased days. White arrows indicate areas of new bone formation, while black arrows indicate the scaffolds (Magnification: ×40). *p < 0.05 vs the CM-ALs (0%) control group.

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