Figure 3 | Scientific Reports

Figure 3

From: Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Figure 3

Dynamic patterns of histone PTMs between asexual and sexual development. (a) Correlation of the overall histone PTM landscape between the eight P. falciparum life cycle stages shows an early asexual cluster and a gametocyte cluster of correlating PTM landscapes (Pearson correlation). Correlation of a subset of 13 conserved residues (H3K4ac, H3K9me1, H3.3K9me2, H3K18me1, H3K23me1, H3K27me2&me3, H3K36me2&me3, H3K56me1&me2, H3K79me3 and H3.3K79me3) between stage I & III (r2 = 0.78), I & V (r2 = 0.70) and III & V (r2 = 0.83) gametocytes are shown in red. (b) Stage-specific trends based on z-score distribution are shown for rings (H3K56me1&me2; H3.3K79me3), trophozoites (H3K9me2; H3K18me1), schizonts (H3K4me2, me3 & ac; H3.3K9me1; H3K122ac; H4K16ac) early gametocytes (H3K27me2 & me3; H3K36me2 & me3; H3.3K79me1) and late gametocytes (H3K4me1; H3K27me1; H3K36me1; H3K79ac & me3; H3.3K79me2).

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