Figure 4
From: A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
The longevity of clk-1 mutants is rescued by 2,4-DHB. (a) Supplementation with 0.15 mM and 1 mM 2,4-DHB fully rescues the lengthened lifespan of clk-1 mutants. (b) Supplementation with either 0.15 mM or 1 mM 2,4-DHB has no effect on the wild type lifespan. (c) Treatment with 1 mM 3,4-DHB does not affect the lifespan of either clk-1 mutants or the wild-type. (d) Treatment with 1 mM 2,4-DHB rescues the lengthened lifespan of clk-1(e2519) mutants and has no effect on wild type lifespan. Sample sizes, numerical values and statistical analyses for all lifespan experiments are presented in Table S2.
