Table 1 Clinical and biochemical characteristics of 20,395 participants classified by alcohol intake status in 2011-2012 and 2013-2014.

	Non-drinkers			Light drinkers			Moderate/Heavy drinkers			All
	2011–2012	2013–2014	p-value	2011–2012	2013–2014	p-value	2011–2012	2013–2014	p-value	2011–2012	2013–2014	p-value
Number	6,264			9,315			4,816			20,395
Sex (male/female)	1,231/5,033			3,543/5,772			4,245/571			9,019/11,376
Age (years)	64.6 (7.7)	67.1 (7.8)		63.4 (8.0)	65.9 (8.0)		62.9 (7.8)	65.4 (7.9)		63.6 (7.9)	66.2 (7.9)
Body weight (kg)	55.8 (10.1)	55.4 (10.3)	<0.001	58.1 (10.2)	57.8 (10.4)	<0.001	64.2 (10.1)	63.9 (10.3)	<0.001	58.8 (10.6)	58.5 (10.8)	<0.001
Body mass index (kg/m²)	23.7 (3.6)	23.6 (3.7)	0.007	23.69 (3.4)	23.65 (3.5)	<0.001	24.1 (3.1)	24.0 (3.2)	<0.001	23.8 (3.4)	23.7 (3.5)	<0.001
Overweight (≥25, %)	32.8	32.0	0.045	31.3	31.2	0.627	35.8	35.1	0.125	32.8	32.3	0.025
Smoking (yes)	7.2	6.7	0.001	10.2	9.5	<0.001	27.9	25.5	<0.001	13.5	12.4	<0.001
Hypertension (%)	53.1	54.5	0.005	50.1	51.3	0.001	62.0	63.2	0.032	53.9	55.1	<0.001
Dyslipidemia (%)	57.9	60.3	<0.001	51.5	56.0	<0.001	35.9	38.8	<0.001	49.8	53.3	<0.001
Diabetes (%)	10.9	13.8	<0.001	9.2	12.2	<0.001	13.0	16.4	<0.001	10.6	13.7	<0.001
AST (U/L)*	22 (19–26)	22 (19–26)	<0.001	23 (20–27)	23 (19–27)	<0.001	25 (21–31)	25 (21–30)	<0.001	23 (20–28)	23 (20–27)	<0.001
ALT (U/L)*	18 (14–24)	17 (14–23)	<0.001	18 (14–25)	18 (14–24)	<0.001	21 (16–30)	21 (16–28)	<0.001	19 (14–26)	18 (14–25)	<0.001
γ-GTP (U/L)*	19 (15–28)	19 (14–27)	<0.001	22 (16–34)	21 (16–31)	<0.001	41 (26–69)	38 (24–64)	<0.001	24 (16–39)	22 (16–36)	<0.001
hepatobiliary enzyme abnormality (%)	21.9	19.3	<0.001	25.1	22.6	<0.001	49.8	46.1	<0.001	29.9	27.1	<0.001

Data are mean values (standard deviation) or *median (interquartile range) for continuous variables, percentage values for categorical variables.
AST, aspartate aminotransferase; ALT, alanineaminotransferase; γ-GTP, gamma-glutamyl transpeptidase.

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