Figure 2
From: Avian and human influenza virus compatible sialic acid receptors in little brown bats
Co-expression of SA α2,3-Gal and SAα2,6-Gal receptors in LBB digestive tract. Composite confocal images show co-expression of both SA α2,3-Gal (red) and SA α2,6-Gal (green) influenza receptors on the mucosal lining of (A) stomach and (B) intestine of the little brown bat (LBB). The SA α2,3-Gal receptor is the predominant receptor type on the mucosal lining of the (A’) stomach and (B’), intestinal villi SA α2,6-Gal receptor type is more prominent in the lamina propria, muscularis and serosa of the (A) stomach and (B) intestine. Tissue sections were stained with biotinylated MAAII (red - specific for avian type receptor, SA α2,3-Gal) and FITC labelled SNA (green - specific for human type receptor, SAα2,6-Gal) lectins, and DAPI nuclear stain (blue). A”: h aematoxylin and eosin (H and E) stained stomach tissue section. 1. mucosa 2. submucosa 3. mucosal glands. B”: H and E stained intestinal tissue section 4. villus, 5. goblet cell, 6. lamina propria, 7. simple columnar epithelial cell layer, 8. submucosa 9. muscularis.
