Table 2 Regulatory genes are commonly high in GU wobble content, while genes involved in immune evasion are low in GU wobble content.

From: Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum

GO ID

GO Term

Fold enrichment

Odds ratio

P-value

a.

 GO:2001141

regulation of RNA biosynthetic process

4.93

5.48

2.47E-11

 GO:0006355

regulation of transcription, DNA-templated

4.93

5.48

2.47E-11

 GO:0051252

regulation of RNA metabolic process

4.8

5.33

4.23E-11

 GO:2000112

regulation of cellular macromolecule biosynthetic process

4.29

4.79

1.01E-10

 GO:0010556

regulation of macromolecule biosynthetic process

4.29

4.79

1.01E-10

 GO:0019219

regulation of nucleobase-containing compound metabolic process

4.26

4.75

1.18E-10

 GO:0051171

regulation of nitrogen compound metabolic process

4.26

4.75

1.18E-10

 GO:0009889

regulation of biosynthetic process

4.26

4.75

1.18E-10

 GO:0031326

regulation of cellular biosynthetic process

4.26

4.75

1.18E-10

 GO:0010468

regulation of gene expression

4.06

4.52

3.38E-10

b.

 GO:0020033

antigenic variation

8.33

12.64

1.55E-62

 GO:0051809

passive evasion of immune response of other organism involved in symbiotic interaction

8.33

12.64

1.55E-62

 GO:0051832

avoidance of defenses of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

 GO:0051834

evasion or tolerance of defenses of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

 GO:0051805

evasion or tolerance of immune response of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

 GO:0051707

response to other organism

8.25

12.51

3.44E-62

 GO:0043207

response to external biotic stimulus

8.25

12.51

3.44E-62

 GO:0052173

response to defenses of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

 GO:0051807

evasion or tolerance of defense response of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

   GO:0052564

response to immune response of other organism involved in symbiotic interaction

8.25

12.51

3.44E-62

  1. (a) The top 10 GO terms enriched in genes with >40% GU wobble content. (b) The top 10 GO terms enriched in genes with <20% GU wobble content.