Table 2 Prediction of BRCA1 germline mutation (n = 45) by multivariate logistic regression (Series III).

From: Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

Variables

n (%)

OR (95% CI)

P

Nestin

 Negative

95 (68.8)

1.0

<0.0005

 Positive

43 (31.2)

5.4 (2.2–13.3)

CK5

 Negative

104 (75.4)

1.0

NS

 Positive

34 (24.6)

1.2 (0.4–3.7)

EGFR

 Negative

116 (84.1)

1.0

NS

 Positive

22 (15.9)

1.2 (0.4–3.8)

P-cadherin

 Negative

68 (49.3)

1.0

0.019

 Positive

70 (50.7)

3.1 (1.2–7.9)

  1. n: number of patients; OR: odds ratio; CI: confidence interval; P: p-values. CK: cytokeratin; EGFR: epidermal growth factor receptor. Cut-off values: CK5 positive: SI(staining index)>0; EGFR positive: >1%, Dako criteria; P-cadherin positive: SI > 3. BRCA2 germline mutated patients were excluded from the analysis. Missing data: EGFR: n = 1. Only cases with information on all variables were included (n = 138).
Back to article page