Table 3 Prediction of BRCA1 germline mutation (n = 13) by multivariate logistic regression in patients below 40 years (Series III).

From: Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

 

n (%)

OR (95% CI)

P

Nestin

 Negative

14 (48.3)

1.0

0.048

 Positive

15 (51.7)

12.9 (1.0–164)

CK5

 Negative

19 (65.5)

1.0

NS

 Positive

10 (34.4)

0.8 (0.1–8.2)

EGFR

 Negative

21 (72.4)

1.0

NS

 Positive

8 (27.6)

1.7 (0.1–22.2)

P-cadherin

 Negative

11 (37.9)

1.0

NS

 Positive

18 (62.1)

0.2 (0.0–6.2)

TNP

 Absent

15 (51.7)

1.0

NS

 Present

14 (48.3)

6.0 (0.4–85.7)

  1. n: number of patients; OR: odds ratio; CI: confidence interval; P: p-values. CK: cytokeratin; EGFR: epidermal growth factor receptor; TNP: triple negative profile. Cut-off values: CK5 positive: SI (staining index)> 0; EGFR positive: >1%, Dako criteria; P-cadherin positive: SI > 3. BRCA2 germline mutated patients were excluded from the analysis. Only cases with information on all variables were included (n = 29).
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