Table 4 BRCA1 germline mutation by Nestin mRNA expression and Nestin mRNA signature score (microarray data).

From: Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

Germline BRCA1

 

Negative n (%)

Positive n (%)

OR (95% CI)

TCGA

Nestin mRNA

 Low

360 (75.9)

4 (36.4)

1.0

 High

114 (24.1)

7 (63.6)

5.5 (1.6–19.2)a,**

Nestin signature score

 Low

361 (76.2)

2 (18.2)

1.0

 High

113 (23.8)

9 (81.8)

14.4 (3.1–67.5)a,***

GSE40115

Nestin mRNA

 Low

100 (78.1)

20 (60.6)

1.0

 High

28 (21.9)

13 (39.4)

2.3 (1.0–5.2)*

Nestin signature score

 Low

107 (83.6)

11 (33.3)

1.0

 High

21 (16.4)

22 (66.7)

10.2 (4.3–24.1)***

GSE25307

Nestin mRNA

 Low

366 (78.2)

17 (50.0)

1.0

 High

102 (21.8)

17 (50.0)

3.6 (1.8–7.3)***

  1. aFisher’s exact test. n: number of patients; OR: odds ratio; CI: confidence interval; P-values by Pearson’s chi-square test, *<0.05, **<0.01, ***<0.001. BRCA2 germline mutated patients are excluded from the analysis. Cut-off value: high: ≥upper quartile. Missing data: BRCA-status: TCGA: n = 23, GSE25307: n = 36.
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