Table 6 Univariate and multivariate survival analysis (Cox’ proportional hazards regression) with death from breast cancer as end-point (Series I).

From: Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

Variables

n

Univariate HR (95% CI)

P

Multivariate HR (95% CI)

P

Tumour diameter

 <2.0 cm

358

1.0

<0.0005

1.0

0.001

 ≥2.0 cm

165

3.7 (2.3–5.9)

2.3 (1.4–3.7)

Histological grade

 1–2

433

1.0

<0.0005

1.0

NS

 3

90

2.4 (1.5–3.9)

1.5 (0.8–2.5)

Nodal status

 Negative

382

1.0

<0.0005

1.0

<0.0005

 Positive

141

4.7 (3.0–7.4)

3.7 (2.3–6.0)

Nestin

 Negative

473

1.0

0.002

1.0

0.035

 Positive

50

2.5 (1.4–4.5)

2.0 (1.1–3.8)

  1. n: number of patients; HR: hazard ratio; CI: confidence interval; P: p-values; NS: not significant. Only patients with information on all variables were included in the analysis (n = 523).
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