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Figure 1

From: Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

Figure 1

Obestatin increases glucose-stimulated insulin secretion (GSIS). β-cells or pancreatic islets were treated with different doses of obestatin in presence of 3.3 or 22.2 mM glucose for 1 hour. Insulin measured was normalized to total protein content of cells or islets. (A) INS-1 cells. (B) Pancreatic islets isolated from ghrelin −/− mice, and tested under glucose concentration of 22.2 mM. #P < 0.05 obestatin treatment vs saline treatment, per glucose concentration, n = 3–5.

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