Figure 1
From: Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture
Edn2KO PND6 pups are smaller but have normal ovarian development. (A) Average body mass at post-natal day 6 (PND6) of WT (4.12 ± 0.25 g) vs Edn2KO (2.25 ± 0.10 g) pups. (B) Representative PND6 WT and Edn2KO ovaries sectioned at 5 μM. Histology images are shown at 10X and 20X. Both ovaries have a mix of germ cells, primordial follicles, primary follicles, and several preantral follicles. (C) Follicle and germ cell counting was performed on PND6 WT and Edn2KO and control ovaries (n = 10). Absolute cell counts are displayed above and the percentage of total cells per ovary is displayed below. A significant difference was seen between the percentage of germ cells present (p = 0.007). No other significant differences were noted. Error bars display the S.E.M.
