Table 2 Summary of the prevalence estimation for thalassemia.

Types	Items		N	n	Cases	Prevalence (%)	Gene frequency (%)	95%CI	I² (%)
α-thalassemia	total		12	84598	7696	7.88	—	5.54~10.23	99.7
	subtypes	--^SEA	9	104578	2958	—	2.54	1.57~3.51	99
		-α^3.7	9	104578	1598	—	1.59	0.93~2.24	98.8
		-α^4.2	9	104578	554	—	0.54	0.31~0.78	96.7
		α^CSα	8	102464	249	—	0.24	0.16~0.32	97.1
		α^WSα	5	94308	355	—	0.26	0.17~0.36	98.9
		α^QSα	9	104578	92	—	0.06	0.02~0.10	88.9
	diagnostic method	gene analysis	11	79198	6859	7.42	—	5.12~9.72	99.6
	diagnostic method	no gene analysis	1	5400	837	15.50	—	14.53~16.47	99.7
	year	1991~2000	3	7434	1055	12.38	—	8.73~16.03	93.9
		2001~2010	6	36752	2716	10.36	—	6.83~13.89	99.4
		2011~	2	27591	3586	9.28	—	1.33~17.23	99.2
β-thalassemia	total		13	439874	6001	2.21	—	1.93~2.48	99.6
	subtypes	CD41/42	7	112712	931	—	0.93	0.54~1.32	98.4
		IVS-2-654	7	112712	448	—	0.25	0.11~0.40	94.8
		CD71/72	6	109260	83	—	0.07	0.03~0.12	92
		CD26	7	112712	68	—	0.07	0.03~0.10	81.9
		-28	6	109260	262	—	0.25	0.11~0.38	96.1
		CD17	7	112712	387	—	0.48	0.30~0.65	97.4
	diagnostic method	gene analysis	10	72598	3353	—	4.39	2.91~5.87	99
	diagnostic method	no gene analysis	3	367276	2648	—	0.92	0.69~1.16	99.5
	year	1981~1990	1	2473	13	0.53	—	0.24~0.82	—
		1991~2000	3	12277	685	6.06	—	4.53~7.59	90
		2001~2010	5	34469	1657	4.92	—	1.90~7.95	99.4
		2011~	3	29317	1246	2.64	—	0.35~4.93	98.3
α+β-thalassemia	total		6	44734	220	0.48	—	0.18~0.79	96
	year	1991~2000	2	4812	27	0.72	—	−0.17~1.61	87.8
		2001~2010	2	12331	22	0.59	—	−0.50~1.67	91.2
		2011~	2	27591	171	0.37	—	−0.17~0.91	96.4

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