Figure 8
From: Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator
Structural comparison of DBD - DNA complexes. (a) Superposition of CadC1-107 and PhoB16 as taken from their complex structures. Shown is the recognition helix and the β-wing with analogous residues that are involved in specific interactions with DNA in at least one of the complex structures/model. Residues were selected from the structure-based alignment shown in (c). (b) The same as in (a) but with PmrA as taken from its complex structure with DNA18. (c) Structure-based sequence alignment of the CadC DBD and the DBDs from PhoB and PmrA with residues contacting DNA as indicated. Arrows above the sequence show residues with a functional impact after mutation in CadC (see Fig. 5).
