Figure 3
From: Paraquat poisoning induced pulmonary epithelial mesenchymal transition through Notch1 pathway
Monolayer wound-healing results of different treatments to A549 cells. A significantly increased migration capacity was observed after Jagged-1 (a Notch1 protein ligand, 500 ng/mL) stimulation, while a decreased capacity upon treated with DAPT (a γ-secretase inhibitor,10 μmol/L). And the migration property of A549 cells decreased apparently after treated with SB431542 (a specific inhibitor of TGF-β receptor type I/ALK5 kinase that phosphorylates Smad2/3, 10 μmol/L).
