Table 3 Bias factor on the different responses in HEK293 and mLTC-1 cells.

From: Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors

HEK293 cells

Bias factor

mLTC-1 cells

Bias factor

ß-arrestin 2/cAMP

1.81 (p = 0.0655)

cAMP/Progesterone

5.25 (p = 0.0034)

Cre -reporter assay/cAMP

4.84 (p = 0.0000177)

cAMP/Testosterone

2.39 (p = 0.0301)

Cre -reporter assay/ß-arrestin 2

2.67 (p = 0.00988)

Testosterone/Progesterone

2.19 (p = 0.0617)

  1. The bias factor values of each response pair reflect the biased agonism of rhLH towards the first response compared to the second, all in comparison to rhCG taken as the reference hormone.
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