Table 2 Minimum Inhibitory Concentration Distributions Among Isolates of the Candida Bloodstream Infection in Children.

From: Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia

Pathogens/antifungals

No. of isolates with MIC (mg/L) of:

MIC (mg/L)

0.008

0.015

0.03

0.06

0.12

0.25

0.5

1.0

2.0

4.0

≥8.0

GM

MIC50

MIC90

Candida albicans (total n = 134 tested)

  Amphotericin B

    

1

10

117

6

   

0.484

0.5

0.5

  Fluconazole

    

5

33

77

15

  

4

0.474

0.5

1.0

  Voriconazole

104

24

2

   

1

1

2

  

0.010

0.008

0.015

  Micafungin

80

31

19

3

1

      

0.119

0.008

0.03

  Caspofungin

1

4

22

95

11

1

     

0.054

0.06

0.06

  Anidulafungin

 

34

28

56

16

      

0.039

0.06

0.12

Candida parapsilosis (total n = 86 tested)

  Amphotericin B

     

6

51

28

   

0.598

0.5

1.0

  Fluconazole

    

2

6

36

32

9

  

0.569

1.0

2.0

  Voriconazole

19

39

21

6

       

0.017

0.015

0.03

  Micafungin

  

1

   

15

49

18

2

 

1.015

1.0

2.0

  Caspofungin

  

1

 

1

4

52

23

4

  

0.592

0.5

1.0

  Anidulafungin

  

1

1

 

1

13

56

13

1

 

0.928

1.0

2.0

Candida glabrata (total n = 10 tested)

  Amphotericin B

      

4

6

   

0.757

1.0

1.0

  Fluconazole

          

10

≥8.0

≥8.0

≥8.0

  Voriconazole

     

1

6

2

1

  

0.615

0.5

2.0

  Micafungin

2

7

       

1

 

0.023

0.015

4.0

  Caspofungin

  

1

1

7

     

1

0.148

0.12

≥8.0

  Anidulafungin

  

6

3

    

1

  

0.056

0.03

2.0

Candida tropicalis (total n = 14 tested)

  Amphotericin B

      

4

10

   

0.82

1

1

  Fluconazole

       

3

7

3

1

5.123

4

8

  Voriconazole

    

5

5

3

   

1

0.285

0.25

0.5

  Micafungin

 

4

10

        

0.024

0.03

0.03

  Caspofungin

  

2

7

2

3

     

0.081

0.06

0.25

  Anidulafungin

  

2

4

6

2

     

0.089

0.12

0.25

Other Candida spp. (total n = 51 tested)

  Amphotericin B

    

3

21

17

7

3

  

0.412

0.5

1.0

  Fluconazole

    

2

2

3

8

13

12

11

2.550

2

8

  Voriconazole

7

4

6

17

10

4

1

   

2

0.060

0.06

0.25

  Micafungin

 

7

4

5

2

11

16

5

1

  

0.180

0.25

1

  Caspofungin

  

5

6

7

21

10

   

2

0.203

0.25

0.5

  Anidulafungin

 

4

2

6

6

7

6

17

3

  

0.278

0.5

1

  1. MIC: minimum inhibitory concentration.
  2. MIC50 and MIC90: MIC required to inhibit 50% and 90% of the isolates, respectively.
  3. GM: geometric mean.
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