Figure 2
Relationships between the early expression levels of candidate genes and post-stroke BBB disruption. (A) Relationships between peripheral blood total transcriptional expression levels of each of the 16 candidate genes at hospital admission and level of HARM on perfusion-weighted imaging at 24 hour follow up. Expression levels are presented as standardized values generated from mean normalized microarray florescence intensities. Significance of relationships between gene expression levels and severe HARM was assessed via bias-reduced logistic regression. (B) Relationship between peripheral blood total transcriptional expression levels of AKAP7 at hospital admission and level of HARM on perfusion weighted imaging at 24 hour follow up. Expression levels are presented as mean normalized microarray florescence intensity and were compared between HARM categories using one-way ANOVA. (C) Receiver operator curve depicting the sensitivity and specificity of admission peripheral blood total AKAP7 levels as an identifier of patients who later developed severe HARM.
