Table 4 Associations between clinical parameters favoring diabetic nephropathy and clinical outcomes in patients with diabetic kidney disease.
DM > 8 years | Diabetic retinopathy | Diagnostic model | |||||||
|---|---|---|---|---|---|---|---|---|---|
− | + | P-value | − | + | P-value | − | + | P-value | |
HR for ESRD | |||||||||
Unadjusted | 1 (reference) | 2.30 (1.50–3.52) | <0.001 | 1 (reference) | 2.56 (1.81–3.61) | <0.001 | 1 (reference) | 4.35 (2.84–6.66) | <0.001 |
Fully-adjusted | 1 (reference) | 1.54 (0.99–2.38) | 0.055 | 1 (reference) | 1.69 (1.16–2.45) | 0.006 | 1 (reference) | 1.66 (1.05–2.61) | 0.029 |
OR for rapid renal progression | |||||||||
Unadjusted | 1 (reference) | 1.43 (1.07–1.90) | <0.001 | 1 (reference) | 2.14 (1.67–2.75) | <0.001 | 1 (reference) | 2.54 (1.96–3.31) | <0.001 |
Fully-adjusted | 1 (reference) | 1.34 (0.96–1.87) | 0.080 | 1 (reference) | 1.55 (1.15–2.09) | 0.004 | 1 (reference) | 1.38 (0.96–1.98) | 0.082 |
HR for all-cause mortality | |||||||||
Unadjusted | 1 (reference) | 0.95 (0.68–1.34) | 0.783 | 1 (reference) | 1.38 (1.01–1.90) | 0.044 | 1 (reference) | 1.66 (1.18–2.32) | 0.003 |
Fully-adjusted | 1 (reference) | 0.80 (0.57–1.15) | 0.143 | 1 (reference) | 1.02 (0.72–1.44) | 0.921 | 1 (reference) | 0.96 (0.65–1.40) | 0.821 |
HR for CV events | |||||||||
Unadjusted | 1 (reference) | 1.30 (0.98–1.73) | 0.069 | 1 (reference) | 1.54 (1.21–1.98) | 0.001 | 1 (reference) | 1.89 (1.45–2.46) | <0.001 |
Fully-adjusted | 1 (reference) | 0.94 (0.73–1.33) | 0.547 | 1 (reference) | 1.33 (1.01–1.74) | 0.045 | 1 (reference) | 1.10 (0.82–1.47) | 0.521 |
